In this week's episode, Sam and Dean learn that in order to rid the world of demons forever, one of them will have to complete several trials from God, starting with killing a hell hound. Yes -- only one of them can complete the trials, and the one that does is in for a world of suffering. When we stopped by the set this week, Jared Padalecki told us that the chosen Winchester will begin to experience nosebleeds and symptoms similar to Tuberculosis... and, as is the Winchester way, he'll try to keep it from his brother. "Try" being the operative word.
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